Hydrochloric Acid → HCID 18937750, compound

Participants

Reaction Steps

To a solution of ethyl 1-(4-methoxybenzyl)-4-(4-dimethoxymethyl-2-nitrobenzoyl)-1,2,3-triazole-5-carboxylate (7.26 g, 15 mmole) obtained in Example 11 (b-1: LP) in tetrahydrofuran (50 ml) was added a 1N aqueous hydrochloric acid solution (30 ml), and the mixture was stirred at room temperature for 16 hours. The reaction mixture was extracted with ethyl acetate, and the organic layer was washed with a saturated aqueous sodium hydrogen carbonate solution. The solvent was removed under reduced pressure to give ethyl 4-(4-formyl-2-nitrobenzoyl)-1-(4-methoxybenzyl)1,2,3-triazole-5-carboxylate as a yellow crystalline powder (6.2 g, 94%).

Provenance & Evidence