HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Phenylprop-2-enenitrile → N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylsulfonylpiperazin-1-yl)-2-styrylpyrimidin-4-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Phenylprop-2-enenitrile | HCID 74667 | — |
| Reactant | 1H-Pyrazol-3-amine, 5-methyl- | HCID 93146 | — |
| Reactant | 1-(Methylsulfonyl)piperazine | HCID 709161 | — |
| Product | N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylsulfonylpiperazin-1-yl)-2-styrylpyrimidin-4-amine | HCID 66738751 | — |
Reaction Steps
Example 71 was synthesized via Scheme 6 according to the general scheme provided above with the appropriate starting materials cinnamonitrile, 5-methyl-1H-pyrazole-3-amine, and 4-methylsulfonylpiperazine. Structure of the target was confirmed by 1H-NMR. The 1H-NMR is attached.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07563787B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-834453af306b4f01ae5cfaeeb7515650 |
| Source note | uspto-grants-2009_07 |