反应详情

温度

22 °C

A solution of N-carbobenzyloxy-L-proline-L-isoleucine benzylamide (36.60 g, 80.95 mmol), 10% palladium on carbon (0.957 g), and methanol (700 mL) was degassed and purged repeatedly (15 times) with hydrogen, and stirred under an atmosphere of hydrogen at 22° C. When TLC analysis indicated the reaction was complete, the solution was purged with argon, filtered through a plug of celite, and concentrated in vacuo to provide 23.71 g, (92%) of L-proline-L-isoleucine benzylamide as a white solid.

1. custompurged repeatedly (15 times) with hydrogen
2. customthe solution was purged with argon
3. filtrationfiltered through a plug of celite
4. concentrationconcentrated in vacuo