HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → HCID 67621198, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 1-(1,1'-Biphenyl)-4-yl-2-bromoethanone | HCID 67282 | — |
| Reactant | HCID 86751513 | HCID 86751513 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 67621198 | HCID 67621198 | 99.6% |
Reaction Steps
Using the procedure described in example 5, treatment of L-proline-L-isoleucine benzylamide (300 mg, 0.95 mmol), with sodium carbonate (200 mg, 1.89 mmol), and 2-bromo-4'-phenylacetophenone (520 mg, 1.89 mmol, 2.0 eq) in acetonitrile (10 mL), provided 484 mg (87%) of L-isoleucine, N-[1-(2-(biphenyl-4-yl)-2-oxoethyl)-L-prolyl] benzylamide as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05686424 |
| Source dataset | uspto-grants-1997_11 |
| ORD ID | ord-da01096b196f4325a6f4661dcee61ab9 |
| Source note | uspto-grants-1997_11 |