反应详情

Using the procedure described in example 5, treatment of L-proline-L-isoleucine benzylamide (317 mg, 0.99 mmol), with sodium carbonate (211 mg, 1.99 mmol), and 2-bromo-2'-methoxyacetophenone (457 mg, 1.99 mmol, 2.0 eq) in acetonitrile (10 mL), provided 410 mg (88%) of L-isoleucine, N-[1-(2-(2-methoxyphenyl)-2-oxoethyl)-L-prolyl] benzylamide as a pale yellow oil.