Sodium Carbonate → HCID 67619825, compound

Participants

Reaction Steps

Using the procedure described in example 5, treatment of L-proline-L-isoleucine benzylamide (182 mg, 0.57 mmol), with sodium carbonate (60 mg, 0.57 mmol), and 2-bromo-4'-chloroacetophenone (147 mg, 0.63 mmol, 1.0 eq), in methanol (10 mL), provided 237 mg (88%) of L-isoleucine, N-[1-(2-(4-chlorophenyl)-2-oxoethyl)-L-prolyl] benzylamide as a pale yellow oil.

Provenance & Evidence