Sodium Carbonate → HCID 67620146, compound

Participants

Reaction Steps

Using the procedure described in example 5, treatment of L-proline-L-isoleucine benzylamide (191 mg, 0.60 mmol), with sodium carbonate (70 mg, 0.66 mmol), and 2-bromo-4'-methylacetophenone (141 mg, 0.66 mmol, 1.1 eq), in methanol (5 mL), provided 210 mg (78%) of L-isoleucine, N-[1-(2-(4-methylphenyl)-2-oxoethyl)-L-prolyl] benzylamide as a pale yellow oil.

Provenance & Evidence