HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 67620088, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Bromomethyl 3-methoxyphenyl ketone | HCID 101294 | — |
| Reactant | HCID 86751513 | HCID 86751513 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 67620088 | HCID 67620088 | 82.2% |
Reaction Steps
Using the procedure described in Example 5, treatment of L-proline-L-isoleucine benzylamide (125 mg, 0.39 mmol), with triethylamine (275 uL, 1,97 mmol, 5 eq), and 2-bromo-3'-methoxyacetophenone (107 mg, 0.47 mmol, 1.2 eq) in THF (20 mL), provided 149.2 mg (81%) of L-isoleucine, N-[1-(2-(3-methoxyphenyl)-2-oxoethyl)-L-prolyl] benzylamide as a pale yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05686424 |
| Source dataset | uspto-grants-1997_11 |
| ORD ID | ord-27c25ad599344a64a6790976d86793fa |
| Source note | uspto-grants-1997_11 |