HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 67634307, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Bromomethyl tricyclo[3.3.1.13,7]dec-1-yl ketone | HCID 197820 | — |
| Reactant | HCID 86751513 | HCID 86751513 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 67634307 | HCID 67634307 | 99% |
Reaction Steps
Using the procedure described in Example 5, treatment of a solution of L-proline-L-isoleucine benzylamide (160.7 mg, 0.50 mmol), with triethylamine (3.53 mL, 2.53 mmol, 5.0 eq), and 1-adamantyl bromomethyl ketone (156 mg, 0.61 mmol, 1.2 eq) in THF (20 mL), provided 180 mg (99%) of L-isoleucine, N-[1-(2-adamantan-1-yl-2-oxoethyl)-L-Prolyl] benzylamide as a white foam.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05686424 |
| Source dataset | uspto-grants-1997_11 |
| ORD ID | ord-57ad4e0bfdbb4ac0a20615078cf857a4 |
| Source note | uspto-grants-1997_11 |