HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → L-Isoleucine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Bromo-t-butylacetate | HCID 21584499 | — |
| Reactant | HCID 86751513 | HCID 86751513 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | L-Isoleucine | HCID 6306 | 254.1% |
Reaction Steps
Using the procedure described in Example 5, treatment of a solution of L-proline-L-isoleucine benzylamide (66 mg, 0.21 mmol), with triethylamine (147 uL, 1.05 mmol, 5.0 eq), and alpha-bromo-tert-butylacetate (68 uL, 0.42 mmol, 2 eq) in THF (5 mL), provided 70 mg (77%) of L-isoleucine, N-[1-(2-(carbo-tert-butoxymethylene)-2-oxoethyl)-L-proline] benzylamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05686424 |
| Source dataset | uspto-grants-1997_11 |
| ORD ID | ord-82b027cfa38f4a0093b46b13b6443453 |
| Source note | uspto-grants-1997_11 |