Triethylamine → L-Isoleucine

Participants

Reaction Steps

Using the procedure described in Example 5, treatment of a solution of L-proline-L-isoleucine benzylamide (69 mg, 0.21 mmol), with triethylamine (151 uL, 1.08 mmol, 5.0 eq), and 1-bromopinacolone (58 uL, 0.43 mmol, 2 eq) in THF (5 mL), provided 35 mg (39%) of L-isoleucine, N-[1-(2-tert-butyl-2-oxoethyl)-L-proline] benzylamide as a colorless oil.

Provenance & Evidence