Triethylamine → HCID 67621263, compound

Participants

Reaction Steps

Using the procedure described in Example 5, treatment of a solution of L-proline-L-isoleucine benzylamide (50 mg, 0.16 mmol), with triethylamine (110 uL, 0.79 mmol, 5.0 eq), and 2-bromo-4'-nitroacetophenone (48 mg, 0.20 mmol, 1.2 eq) in THF (5 mL), provided crude material that was additionally purified by preparative TLC to provide 8.8 mg (12%) of L-isoleucine, N-[1-(2-(4-nitrophenyl)-2-oxoethyl)-L-prolyl] benzylamide.

Provenance & Evidence