Triethylamine → HCID 67621477, compound

Participants

Reaction Steps

Using the procedure described in Example 5, treatment of a solution of L-proline-L-isoleucine benzylamide (56 mg, 0.18 mmol), with triethylamine (123 uL, 0.88 mmol, 5.0 eq), and 2-bromo-4'-fluoroacetophenone (37 mg, 0.21 mmol, 1.2 eq) in THF (7 mL), provided a crude product. A portion of the product was purified by preparative TLC to provide 28 mg (35%) of L-isoleucine, N-[1-(2-(4-fluorophenyl)-2-oxoethyl)-L-prolyl] benzylamide.

Provenance & Evidence