4-Bromophenacyl bromide → HCID 67619661, compound

Participants

Reaction Steps

Using the procedure described in Example 5, treatment of a solution of L-proline-L-isoleucine benzylamide (57 mg, 0.18 mmol), with triethylamine (130 uL, 0.93 mmol, 5.0 eq), and 2,-4'-dibromoacetophenone (63 mg, 0.22 mmol, 1.2 eq) in THF (7 mL), provided a crude product. A portion of the product was purified by preparative TLC to provide 62 mg (67%) of L-isoleucine, N-[1-(2-(4-bromophenyl)-2-oxoethyl)-L-prolyl] benzylamide.

Provenance & Evidence