HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → L-Isoleucine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Bromomethyl tricyclo[3.3.1.13,7]dec-1-yl ketone | HCID 197820 | — |
| Reactant | HCID 131720272 | HCID 131720272 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | L-Isoleucine | HCID 6306 | 221.8% |
Reaction Steps
Using the procedure described in Example 5 and Example 17, L-homoproline-L-isoleucine benzylamide (75 mg, 0.22 mmol), was treated with triethylamine (0.15 mL, 1.12 mmol, 5 eq), 1-adamantyl bromomethyl ketone (92 mg, 0.36 mmol, 1.6 eq), and THF (10 mL), to provide 64 mg (56%) of L-isoleucine, N-[1-(2-adamantan-1-yl-2-oxoethyl)-L-homoproline] benzylamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05686424 |
| Source dataset | uspto-grants-1997_11 |
| ORD ID | ord-0c604d24cd504661a22d4c46df48077e |
| Source note | uspto-grants-1997_11 |