2-Furancarboxylic acid → HCID 67619614, compound

Participants

Reaction Steps

Using the procedure described in Example 5, a solution of L-proline-L-isoleucine benzylamide (114 mg, 0.36 mmol), and triethylamine (0.10 mL, 0.78 mmol, 2.0 eq), in THF (10 mL), was treated with 255 mg (1.76 mmol, 5.0 eq) of 2-(alpha-chloroacyl)furan (prepared from 2-furoic acid, using the procedure described in example 1) to provide 130 mg, (85%) of L-isoleucine, N-[1-(2-furan-2-yl-2-oxoethyl)-L-prolyl] benzylamide.

Provenance & Evidence