Picolinic acid → HCID 67619906, compound

Participants

Reaction Steps

Using the procedure described in Example 5, a solution of L-proline-L-isoleucine benzylamide (148 mg, 0.47 mmol), and triethylamine (0.13 mL, 0.93 mmol, 2.0 eq) in THF (10 mL), was treated with 234 mg (1.50 mmol) of 2-(alpha-chloroacyl)pyridine (prepared from picolinic acid, using the procedure described in example 1) to provide 20 mg, (10%) of L-isoleucine, N-[1-(2-pyrid-2-yl-2-oxoethyl)-L-prolyl] benzylamide.

Provenance & Evidence