Triethylamine → HCID 131720275, compound

Participants

Reaction Steps

Using the procedure described in Example 5, a solution of L-proline-L-isoleucine benzylamide (164 mg, 0.51 mmol), and triethylamine (355 uL, 5.0 eq) in THF (2 mL), was treated with 180 mg (2.0 eq) of 1-chloro-2-(1-methyl-cyclohexyl)-2-oxoethane (prepared from 1-methyl-1-cyclohexanecarboxylic acid using the procedure described in example 1) to provide 183 mg (93%) of L-isoleucine, N-[1-(2-(1-methyl-cyclohexyl)-2-oxoethyl)-L-prolyl] benzylamide as a colorless residue.

Provenance & Evidence