Triethylamine → HCID 131720277, compound

Participants

Reaction Steps

Using the procedure described in Example 5, a solution of L-proline-L-isoleucine benzylamide (162 mg, 0.51 mmol), and triethylamine (358 uL, 5.0 eq), in THF (2 mL), was treated with 246 mg (1.0 eq) of 1-chloro-2-oxo-3-(3-methyl-adamantan-1-yl) -propane (prepared from 3-methyl-1-adamantaneacetic acid using the procedure described in example 1) to provide 210 mg (78%) of L-isoleucine, N-[1-(2-oxo-3-(3-methyl-adamantan-1-yl)-propyl)-L-prolyl] benzylamide as a colorless residue.

Provenance & Evidence