反应详情

温度

22 °C

Using the hydrogenation conditions described in example 4, a solution of L-isoleucine, N-[1-(2-benzyloxy-2-oxoethyl)-L-prolyl] benzylamide (14.80 g, 31.76 mmol), 10% palladium on carbon (0.80 g), and methanol (350 mL), was purged with hydrogen, and stirred under an atmosphere of hydrogen at 22° C. After 8 hrs, the solution was purged with argon, filtered through a plug of celite, and concentrated in vacuo to provide 11.47 g, (96%) of L-isoleucine, N-[1-(carboxymethyl)-L-prolyl] benzylamide as a white solid.

1. customthe solution was purged with argon
2. filtrationfiltered through a plug of celite
3. concentrationconcentrated in vacuo