1-Phenyl-1-propanol → HCID 131720290, compound

Participants

Reaction Steps

A solution of L-isoleucine, N-[1-(carboxymethyl)-L-prolyl] benzylamide (59 mg, 0.16 mmol), 4-N,N-dimethylaminopyridine (7.9 mg, 0.06 mmol, 0.4 eq), 1,3-dicyclohexylcarbodiimide (49 mg, 0.23 mmol, 1.5 eq) in dichloromethane (5.0 mL) was treated with (±) 1-phenyl-1-propanol (28 uL, 0.20 mmol, 1.3 eq). After TLC indicated the reaction was complete, the mixture was purified by HPLC to provide 32 mg (41%) of L-isoleucine, N-[1-(2-(1-phenylpropoxy)-2-oxoethyl)-L-prolyl] benzylamide.

Provenance & Evidence