反应详情

温度

22 °C

To a round bottomed flask equipped with a magnetic stirrer was added 4-nitrocinnamyl alcohol (2.0 g, 11.16 mmol), 10% Pd on carbon (200 mg) and absolute ethanol (150 mL). The solution was purged with hydrogen and stirred at 22° C. under a hydrogen atmosphere. When TLC indicated the reaction was complete (4 hr), the solution was purged with argon and filtered through Celite. The filtrate was concentrated in vacuo to provide 3-(4-aminophenyl)propanol, 1.72 g (>100%), as a viscous oil which solidified on standing.

1. customTo a round bottomed flask equipped with a magnetic stirrer
2. customThe solution was purged with hydrogen
3. custom(4 hr)
4. customthe solution was purged with argon
5. filtrationfiltered through Celite
6. concentrationThe filtrate was concentrated in vacuo