Bicyclo[2.2.1]heptane-2-carboxylic acid → L-Isoleucine

Participants

Reaction Steps

Using the procedure described in Example 5, treatment of L-proline-L-isoleucine benzylamide (100 mg, 0.32 mmol) with 2-norbornyl α-chloromethyl ketone (82 mg, 0.48 mmol, 1.5 eq; prepared from 2-norbornanecarboxylic acid by the method described in Example 1) provided 69 mg of L-isoleucine, N-[1-(2-bicyclo[2.2.1]hept-2-yl)-2-oxoethyl)-L-prolyl] benzylamide.

Provenance & Evidence