4-(2-phenoxyethoxy)benzoic acid → HCID 67619421, compound

Participants

Reaction Steps

Using the procedure described in Example 5, treatment of L-proline-L-isoleucine benzylamide (200 mg, 0.63 mmol) with 4'-phenoxyethoxy-2-chloroacetophenone, (275 mg, 0.95 mmol, 1.5 eq; prepared from 4-(2-phenoxyethoxy)benzoic acid by the method described in example 1), provided 80 mg of L-isoleucine, N-[1-{2-oxo-2-[4-(2-phenoxyethoxy)-phenyl]-ethyl}-L-prolyl] benzylamide as a crystalline solid.

Provenance & Evidence