Tetrabutylammonium Fluoride Trihydrate → HCID 11618730, compound

Participants

Reaction Steps

A mixture of 0.81 g (1.63 mmol) of 5-(2-trimethylsilylethynyl)-N-{1-methyl-1-[3-methyl-4-(3-oxomorpholin-4-yl)phenylcarbamoyl]ethyl}thiophene-2-carboxamide and 0.57 g (1.79 mmol) of tetrabutylammonium fluoride trihydrate in 30 ml of methylene chloride is stirred for 2 h and then the organic phase is washed 3× with water, dried with sodium sulphate, filtered and concentrated in vac. The crude product is purified by chromatography (silica gel, methylene chloride→methylene chloride:ethanol 25:1).

Provenance & Evidence