Phosphorus oxychloride → 2-Chloro-6-(4-fluorophenyl)-5-[4-(methylthio)phenyl]-pyridine-3-carbonitrile

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Reaction Steps

A solution of 6-(4-fluorophenyl)-1,2-dihydro-5-[4-(methylthio)phenyl]-2-oxo-pyridine-3-carbonitrile (Example 1, Step 5) (3.7 g, 0.011 mole) in phosphorus oxychloride (45 ml) was stirred at 100° C. for 20 hours. After evaporation of the phosphorus oxychloride the residue was purified by silica gel chromatography and recrystallized from ethyl acetate-hexane.

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