Dimethylamine → HCID 53940149, compound

Participants

Reaction Conditions

Reaction Steps

2-Chloro-6-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]pyridine-3-carbonitrile (Example 7) (200 mg, 0.52 mMol) in ethanol (150 ml) was charged with dimethylamine. The solution was shaken for 24 hours at 70° C. and a pressure of 22 psi in a Parr shaker. The solution was concentrated. The residue was titurated with methyl alcohol and filtered to give a yellow solid: m.p. (DSC): 205.02° C. Anal. Calc'd. for C21H18 N3O2SF (395.46): C, 63.78; H, 4.59; N, 10.63. Found: C, 64.02; H, 4.58; N, 10.77.

Provenance & Evidence