Phosphorus oxychloride → HCID 53913829, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 75 mg (0.20 mMol) of the product of Example 21 and 5 ml of POCl3 was heated to 100° C. for 2 hours, cooled to room temperature, poured into ice-water and extracted with dichloromethane (4×15 ml). The combined organic layers were extracted once with brine, dried over MgSO4 and evaporated to dryness to recover a colorless oil. Trituration with ether gave a colorless solid which was dried at 0.1 mm Hg at 50° C. to give 29.9 mg (42%) of solid: m.p. 178°-181.5° C.

Provenance & Evidence