Acetone → HCID 21476885, compound

HRID 2293483Notes

Reaction equation

HRID 2293483 reaction equation
[CH3:1][C:2]1[CH:15]=[CH:14][CH:13]=[CH:12][C:3]=1[O:4][CH2:5][CH:6]1[O:10][C:9]([NH2:11])=[N:8][CH2:7]1.[CH3:16][C:17]([CH3:19])=O>>[CH2:16]([NH:11][C:9]1[O:10][CH:6]([CH2:5][O:4][C:3]2[CH:12]=[CH:13][CH:14]=[CH:15][C:2]=2[CH3:1])[CH2:7][N:8]=1)[CH2:17][CH3:19]

Participants

3

Reactant 2

HCID 180AcetoneHCID 10176633169137-04-6

Product 1

HCID 21476885HCID 21476885, compound

Procedure

In a reactor are introduced 0,01 mol of 5-[(2-methylphenoxy)methyl]-4,5-dihydro-oxazol-2-ylamine and 100 ml of acetone. Once dissolution is complete, 0,005 mol of 1-bromopropyl are added and the whole is heated to ebullition during 48 hours. After filtering off the formed solid and evaporating the solvent, the crude desired product is purified by separation by column chromatography (eluent: chloroform/ammonia, 95:5).

Workup

  1. dissolutionOnce dissolution
  2. addition0,005 mol of 1-bromopropyl are added
  3. temperaturethe whole is heated
  4. filtrationAfter filtering off the formed solid
  5. customevaporating the solvent
  6. customthe crude desired product is purified by separation by column chromatography (eluent: chloroform/ammonia, 95:5)

Sources & evidence

ORD record
ord-78e30df230a6459abf46e947c99ac0f8
Source dataset
uspto-grants-1997_11
Patent number
US05686477

Reaction notes

Loading…