反应详情

温度

0 °C

A 2.00 g portion of 2-methoxy-4-methylbenzoic acid was dissolved in 10 ml of sulfuric acid. With stirring at 0° C., 0.88 ml of concentrated nitric acid was added thereto dropwise. After 4 hours of stirring at room temperature, and ice water was added. The thus formed crystals were collected by filtration, dried under a reduced pressure and then purified by column chromatography (chloroform:methanol=30:1) to give 1.32 g of 2-methoxy-4-methyl-5-nitrobenzoic acid as yellow crystals.

1. stirringAfter 4 hours of stirring at room temperature
2. filtrationThe thus formed crystals were collected by filtration
3. customdried under a reduced pressure
4. custompurified by column chromatography (chloroform:methanol=30:1)