Nitric Acid → HCID 21477055, compound

HRID 2293557Notes

Reaction equation

HRID 2293557 reaction equation
[CH:1]1([C:4]([NH:6][C:7]2[CH:15]=[CH:14][C:10]([C:11]([OH:13])=[O:12])=[C:9]([O:16][CH3:17])[CH:8]=2)=[O:5])[CH2:3][CH2:2]1.[N+:18]([O-])([OH:20])=[O:19]>C(OC(=O)C)(=O)C.C(O)(=O)C>[CH:1]1([C:4]([NH:6][C:7]2[C:15]([N+:18]([O-:20])=[O:19])=[CH:14][C:10]([C:11]([OH:13])=[O:12])=[C:9]([O:16][CH3:17])[CH:8]=2)=[O:5])[CH2:3][CH2:2]1

Participants

5

Reactant 2

HCID 944Nitric AcidHCID 21477014HCID 21477014, compound

Product 1

HCID 21477055HCID 21477055, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 7918Acetic AnhydrideSolvent

Procedure

A 780 mg portion of 4-cyclopropylcarbonylamino-2-methoxybenzoic acid was dissolved in 10 ml of acetic anhydride and 0.5 ml of acetic acid, and 790 μl of concentrated nitric acid was slowly added to the above solution under ice-cooling, followed by 2 hours of stirring. The reaction solution was poured into ice water, and the thus formed precipitate was collected by filtration and dried under a reduced pressure to give 713 mg of 4-cyclopropylcarbonylamino-2-methoxy-5-nitrobenzoic acid.

Workup

  1. temperaturecooling
  2. filtrationthe thus formed precipitate was collected by filtration
  3. customdried under a reduced pressure

Sources & evidence

ORD record
ord-1760c16b66884152a861aba3e9e4264b
Source dataset
uspto-grants-1997_11
Patent number
US05686482

Reaction notes

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