Methyl 4-(bromomethyl)benzoate → HCID 21476912, compound

Participants

Reaction Steps

Using the general procedure described in Example 6 the dianion derived from the product of Example 1 (2.503 g; 6.93 mmol) was alkylated with methyl 4-bromomethylbenzoate. The crude reaction mixture was partitioned between EtOAc and 10% aqueous NaHSO4, separated dried and evaporated. The residue was purified on a silica gel flash chromatography eluted with CHCl3 -MeOH--NH4OH (80:15:1). Evaporation of the purified fractions and drying in vacuo afforded 2.987 g (84%) of the title compound.

Provenance & Evidence