Ethyl bromoacetate → HCID 21476981, compound

HRID 2293607Notes

Reaction equation

HRID 2293607 reaction equation
[C:1]([CH2:6][O:7][C:8]1[CH:9]=[C:10]2[C:14](=[CH:15][CH:16]=1)[N:13]([CH2:17][C:18]1[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][C:19]=1[O:26][CH2:27][C:28]([O:30]CC)=[O:29])[C:12]([C:33]([O:35]CC)=[O:34])=[C:11]2[C:38]1[CH:43]=[CH:42][C:41]2[O:44][CH2:45][O:46][C:40]=2[CH:39]=1)([O:3]CC)=[O:2].C(COC1C=C(OC)C=CC=1CN1C2C(=CC(O)=CC=2)C(C2C=CC3OCOC=3C=2)=C1C(OCC)=O)(OCC)=O.BrCC(OCC)=O>>[C:1]([CH2:6][O:7][C:8]1[CH:9]=[C:10]2[C:14](=[CH:15][CH:16]=1)[N:13]([CH2:17][C:18]1[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][C:19]=1[O:26][CH2:27][C:28]([OH:30])=[O:29])[C:12]([C:33]([OH:35])=[O:34])=[C:11]2[C:38]1[CH:43]=[CH:42][C:41]2[O:44][CH2:45][O:46][C:40]=2[CH:39]=1)([OH:3])=[O:2]

Participants

4

Reactant 3

HCID 7748Ethyl bromoacetateHCID 21476956HCID 21476956, compoundHCID 21476972HCID 21476972, compound

Product 1

HCID 21476981HCID 21476981, compound

Procedure

Ethyl 5-carboethoxymethoxy-1-(2-carboethoxymethoxy-4-methoxybenzyl)-3-(3,4-methylenedioxyphenyl)indole-2-carboxylate. The title compound was prepared from ethyl 1-(2-carboethoxymethoxy-4-methoxybenzyl)-5-hydroxy-3-(3,4-methylenedioxyphenyl)indole-2-carboxylate (150 mg, 0.26 mmol) and ethyl bromoacetate (55 mg, 0.33 mmol) by the method given in example 7b (119 mg, 69%).

Sources & evidence

ORD record
ord-d9adcbb9f3de4e09aa0d915145a12902
Source dataset
uspto-grants-1997_11
Patent number
US05686481

Reaction notes

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