2-Aminobenzenesulfonic acid → HCID 10803520, compound

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Reaction Steps

Orthanilic acid (1 kg) and α-methylstyrene (683g) are mixed with stirring in water (4.631) and heated at reflux for 8 hours. Further portions (2×148 g) of α-methylstyrene are added over 30 minute periods with refluxing for 6 hours. The mixture is filtered at 85° C. and the recovered solid product washed with boiling water and then with ethanol and dried in a vacuum oven. The product is stirred with ether (150ml), filtered off and dried. Recrystallisation from 50% aqueous ethanol affords 1-amino-4-(α,α-dimethylbenzyl)benzene-2-sulphonic acid, m.p. 263°-265° C.

Provenance & Evidence