Toluene → HCID 178470718, compound

Participants

Reaction Steps

To a stirred solution of 1-((S)-Nα -t-butoxycarbonyl-Nω -nitroarginyl)-4-(ethoxycarbonylmethyl)piperidine (1.2 g) in dichloromethane (25 ml) cooled to 0° to 5° C. is slowly added trifluoroacetic acid (2.8 g) and the reaction mixture is allowed to warm to room temperature and is then stirred for 6 hours. Toluene (30 ml) is then added and the mixture is concentrated by evaporation and then co-evaporated with further toluene portions (2×30 ml) and the eventual residue is triturated with ether, collected by filtration, washed with ether and dried to constant weight in vacuo to give 1-((S)-Nω -nitroarginyl)-4-(ethoxycarbonylmethyl)-piperidine trifluoroacetate as a white solid, Rf (BuOH/CH3COOH/H2O 3:2:1)=0.50.

Provenance & Evidence