Hydrochloric Acid → Zantac

Participants

Reaction Conditions

Reaction Steps

One equivalent (about 5.3 ml) of concentrated hydrochloric acid was added to a solution of ranitidine (20 g) in a mixture of propan-2-ol (300 ml) at 45° C. The mixture was heated to 50° C. and then 0.4 g pyridine was added to the reaction mixture. The resulting solution was stirred at 50° C. to allow the product to crystallize. The slurry was cooled to 10°-12° C. and the product was filtered off, washed with propan-2-ol (2×27 ml) and dried at 50° C. under reduced pressure to give 22 g Form II ranitidine hydrochloride having a melting point of 139°-141° C.

Provenance & Evidence