Trimethylsilyl iodide → HCID 131720074, compound

HRID 2293638Notes

Reaction equation

HRID 2293638 reaction equation
[I:1][Si](C)(C)C.[CH3:6][Si:7]([O:10][C:11]([C:13]1[N:18]2[C:19](=[O:26])[CH:20]([NH:21][Si:22]([CH3:25])([CH3:24])[CH3:23])[C@H:17]2[S:16][CH2:15][C:14]=1[CH:27]=[CH:28][CH2:29]OC(=O)C)=[O:12])([CH3:9])[CH3:8]>>[CH3:6][Si:7]([O:10][C:11]([C:13]1[N:18]2[C:19](=[O:26])[CH:20]([NH:21][Si:22]([CH3:25])([CH3:24])[CH3:23])[C@H:17]2[S:16][CH2:15][C:14]=1[CH:27]=[CH:28][CH2:29][I:1])=[O:12])([CH3:9])[CH3:8]

Participants

3

Reactant 2

HCID 85247Trimethylsilyl iodideHCID 131720072HCID 131720072, compound

Product 1

HCID 131720074HCID 131720074, compound

Procedure

0.71 ml of iodotrimethylsilane are added at 0° to the solution, produced as described under a), of 7-trimethylsilylamino-3-(3-acetoxy-1-propen1-yl)-3-cephem-4-carboxylic acid trimethylsilyl ester. The solution is stirred for 15 hours at 0°. Due to the extreme hydrolyzability, characterization is again effected by NMR.

Workup

  1. customproduced

Sources & evidence

ORD record
ord-e0731dc5757a4370b74db8c0993b0850
Source dataset
uspto-grants-1997_11
Patent number
US05686604

Reaction notes

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