Trimethylsilyl iodide → HCID 131720074, compound

HRID 2293639Notes

Reaction equation

HRID 2293639 reaction equation
[I:1][Si](C)(C)C.[CH3:6][Si:7]([O:10][C:11]([C:13]1[N:18]2[C:19](=[O:26])[CH:20]([NH:21][Si:22]([CH3:25])([CH3:24])[CH3:23])[C@H:17]2[S:16][CH2:15][C:14]=1[CH:27]=[CH:28][CH2:29]OC=O)=[O:12])([CH3:9])[CH3:8]>ClCCl>[CH3:6][Si:7]([O:10][C:11]([C:13]1[N:18]2[C:19](=[O:26])[CH:20]([NH:21][Si:22]([CH3:25])([CH3:24])[CH3:23])[C@H:17]2[S:16][CH2:15][C:14]=1[CH:27]=[CH:28][CH2:29][I:1])=[O:12])([CH3:9])[CH3:8]

Participants

4

Reactant 2

HCID 85247Trimethylsilyl iodideHCID 131720075HCID 131720075, compound

Product 1

HCID 131720074HCID 131720074, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2.5 ml of iodotrimethylsilane are added at 0° to the solution of 7-trimethylsilylamino-3-(3-formyloxy1propen1-yl)-3-cephem-4-carboxylic acid trimethylsilyl ester obtained in Example 2a) in dichloromethane, and the solution is stirred for 41/2 hours at 0°. The NMR-spectroscopic data are identical to the data given in Example 1.

Sources & evidence

ORD record
ord-1460c724263840c4ace48a2704806bd6
Source dataset
uspto-grants-1997_11
Patent number
US05686604

Reaction notes

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