Dichloromethane → HCID 178465299, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 5 (0.76 mmol), pyrimidine-5-boronic acid (0.105 g, 0.85 mmol), sodium carbonate (0.292 g, 2.75 mmol), and [1,1′-Bis(diphenylphosphino)ferrocene]dichloropalladium(II) complex with dichloromethane (0.007 g, 8.6 μmol) in 6 mL of 7:3:2 dimethoxyethane/water/ethanol was heated for 30 minutes at 80° C. in a CEM microwave reactor. The reaction was acidified with 2 mL glacial acetic acid and evaporated in vacuo. The residue was purified by silica gel chromatography (gradient elution 0-50% isopropanol in dichloromethane) to give the target compound (4). MS (APCI)=295.1 [M+H].

Provenance & Evidence