4-Phenylbutyric Acid → HCID 70065887, compound

Participants

Reaction Steps

To a stirred solution of 1.00 g of 4-phenylbutyric acid and 60 mg of N,N-dimethylaminopyridine in 20 ml of dichloromethane is added 0.75 ml of ethyl salicylate, followed by 0.95 ml of diisopropyl carbodiimide. After 18 hours, the mixture is concentrated under reduced pressure, and the residue triturated with ether. The organic phase is washed with aq. sodium bicarbonate and brine, dried (magnesium sulfate), and concentrated under reduced pressure. Flash chromatography on silica with 10% ethyl acetate in hexane affords 1.61 g of the title product as a colorless oil.

Provenance & Evidence