Benzhydrol → HCID 54711509, compound

Participants

Reaction Steps

To a mixture of 324 mg of 4-hydroxycoumarin and 368 mg of commercially available diphenylcarbinol in 30 mL of dioxane is added 0.37 mL of boron trifluoride etherate. After 100 hours at room temperature the reaction solution is diluted with 40 mL of diethyl ether and washed with water. The organic phase is dried (magnesium sulfate) and concentrated under reduced pressure. The residue is flash column chromatographed with 20% to 80% ethyl acetate in hexanes to give 587 mg of the title product.

Provenance & Evidence