反应详情

To a stirring suspension of 1.10 g of lithium aluminum hydride in 50 mL of diethyl ether under an argon atmosphere at 0° C. is slowly added a solution of 5.30 g of commercially available 1,3-diphenylacetone in 10.0 mL of diethyl ether with a 10 mL rinse. After 0.25 hours the grey suspension is warmed to room temperature. After 1.5 hours the reaction mixture is re-cooled to 0° C. and slowly treated with 1.2 mL of water followed by 5.0 mL of 1N sodium hydroxide. After 1 hour the resulting white precipitant is filtered through a pad of magnesium sulfate with diethyl ether washings. The filtrate is concentrated under reduced pressure to afford 5.2 g, of the title product as a viscous, clear, colorless oil. This product may be used directly in the next reaction without further purification. Physical characteristics are as follows:

1. washrinse
2. temperatureAfter 1.5 hours the reaction mixture is re-cooled to 0° C.
3. additionslowly treated with 1.2 mL of water
4. filtrationAfter 1 hour the resulting white precipitant is filtered through a pad of magnesium sulfate with diethyl ether washings
5. concentrationThe filtrate is concentrated under reduced pressure
6. customto afford 5.2 g