N,N-Dimethylacrylamide → HCID 11289559, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of nitrile 4 (0.500 g, 1.7 mmol), 0.50 g trifluoroacetamide and 0.25 g dimethylaminoacrolein in 5 mL ethanol was heated to 125° C. for 2 h by microwave irradiation (CEM, 300 watt). The reaction was then evaporated in vacuo and the residue was purified by silica gel chromatography (gradient elution: 0-20% ethyl acetate/dichloromethane) to give pyrimidine 5.

Provenance & Evidence