5-Methyl-2-thiophenecarboxaldehyde → α-Ethyl-5-methyl-2-thiophenemethanol

Participants

Reaction Conditions

Reaction Steps

5-Methyl-2-thiophenecarboxaldehyde (10.0 g) is dissolved in THF and cooled to -78° C. To that solution is added ethyl magnesium bromide (1M in hexane; 80 cc) dropwise over several minutes. The cooling bath is removed and the reaction allowed to equilbrate to room temperature. The reaction is quenched by adding a saturated solution of NH4Cl. The reaction is extracted with ether, dried and evaporated to yield the title product as an almost colorless oil.

Provenance & Evidence