Trifluoroacetic acid → HCID 70065380, compound

Participants

Reaction Steps

To a methylene chloride solution of 2H-cycloocta[b]pyran-2-one of formula II-3 (196 mg) and cyclopropyl benzothien-2-yl carbinol of Preparation 65 (204 mg) is added several drops of TFA. The reaction is stirred for 30 minutes at room temperature without reaction. Several addition drops of TFA is added and the reaction stirred an additional 30 minutes. The solvent is removed in vacuo and the resulting solid dissolved in hot 40% EtOAc/hexane and placed in the freezer over night. The solid is collected on a filter to yield 257.5 mg of the title product.

Provenance & Evidence