Ethyl Acetate → HCID 86751603, compound

Participants

Reaction Steps

Cyclopropyl (5-hydroxymethylfuran-2-yl) carbinol of Preparation 66 (336 mg) and 2H-cycloocta[b]pyran-2-one of formula JJ-3 (427 mg) are dispersed in methylene chloride (25 mL) at 23° C. and trifluoroacetic acid (4 drops) is added. The reaction is stirred for 2.5 h, then poured into EtOAc (400 mL) and washed with water (2×50 mL) and brine. Drying over MgSO4, filtration and concentration in vacuo affords a yellow foam. The product is isolated via column chromatography (150 g silica gel), eluting with 30% EtOAc in CH2Cl2, giving the title product (275 mg) as a white foam.

Provenance & Evidence