3-Amino-2-chloro-4-methylpyridine → 2-Chloro-4-phenylpyridin-3-amine

HRID 2293705Notes

Reaction equation

HRID 2293705 reaction equation
[NH2:1][C:2]1[C:3]([Cl:9])=[N:4][CH:5]=[CH:6][C:7]=1[CH3:8]>C(Cl)Cl>[NH2:1][C:2]1[C:3]([Cl:9])=[N:4][CH:5]=[CH:6][C:7]=1[C:8]1[CH:5]=[CH:6][CH:7]=[CH:2][CH:3]=1

Participants

3

Reactant 1

HCID 27563873-Amino-2-chloro-4-methylpyridine

Product 1

HCID 108220922-Chloro-4-phenylpyridin-3-amine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

adjusting the pH of the aqueous phase to between 3.5 and 5 by the addition of a base, and isolating the 3-amino-2-chloro-4-methyl-pyridine so produced by extraction into methylene chloride, followed by evaporation of the methylene chloride.

Workup

  1. additionby the addition of a base
  2. customfollowed by evaporation of the methylene chloride

Sources & evidence

ORD record
ord-65a470b35fd84179ae210ee8a55d130f
Source dataset
uspto-grants-1997_11
Patent number
US05686618

Reaction notes

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