Benzyl 4-(3-nitropyridin-2-yl)piperazine-1-carboxylate → HCID 21477686, compound

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Reaction Steps

1-[Benzyloxycarbonyl]-4-[3-nitro-2-pyridinyl]piperazine (PREPARATION 32), is dissolved in dioxane (923 ml) and cooled to 0°. Then aqueous titanium trichloride (20%, 555.3 ml) is added cautiously. After stirring 30 min the reaction is diluted with aqueous sodium hydroxide solution (2N, 1.5 l) and filtered through celite. The filter cake is washed with methanol/chloroform (10/90). The combined organic layers are washed with water, saline, dried and concentrated in vacuo to afford the desired product, NMR (300 MHz, CDCl3) 7.80, 7.38-7.32, 6.99, 6.88, 5.17, 3.67 and 3.12 δ.

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