Aluminium lithium hydride → HCID 21477684, compound

HRID 2293754Notes

Reaction equation

HRID 2293754 reaction equation
[F:1][CH2:2][C:3]([NH:5][C:6]1[C:7]([N:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)=[N:8][CH:9]=[CH:10][CH:11]=1)=O.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[F:1][CH2:2][CH2:3][NH:5][C:6]1[C:7]([N:12]2[CH2:13][CH2:14][NH:15][CH2:16][CH2:17]2)=[N:8][CH:9]=[CH:10][CH:11]=1

Participants

3

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 21477654HCID 21477654, compound

Product 1

HCID 21477684HCID 21477684, compound

Procedure

Following the general procedure of PREPARATION 36 and making non-critical variations but starting with 1-[3-(2-fluoroacetamido)-2-pyridinyl]- piperazine (PREPARATION 37, 1.4 g), lithium aluminum hydride (11.76 ml, 1M in tetrahydrofuran), the title compound is obtained.

Workup

  1. customthe general procedure of PREPARATION 36

Sources & evidence

ORD record
ord-790b349a370c4fc192b9806f1b55ae74
Source dataset
uspto-grants-1997_11
Patent number
US05686610

Reaction notes

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