147539-53-5 → HCID 21477660, compound

Participants

Reaction Steps

A flask is charged with platinum oxide (250 mg) and absolute ethanol (20 ml) and is stirred under a hydrogen atmosphere (balloon) for 1 hr. Then a solution of 1-(1,1-dimethylethoxycarbonyl)-4-(1,1-dimethylprop-2-ynyl)piperazine (PREPARATION 68, 1.77 g) in absolute ethanol (20 ml) is added, and the mixture is stirred under hydrogen (balloon) for 4 hr, filtered, and concentrated. The residue is chromatographed on silica gel (70-230 mesh, 80 g), eluting with ethyl acetate/hexane (25/75), and the appropriate fractions (Rf =0.32, TLC, ethyl acetate/hexane, 25/75) are pooled and concentrated to give the title compound, NMR (CDCl3) 3.38, 2.46, 1.46-1.38, 0.97 and 0.84.

Provenance & Evidence